What is DeepCalpain

DeepCalpain is a web server based on deep learning to predict calpain-specific cleavage events. Given a protein or a set of proteins in FASTA format, it can predict the possible cleavage sites of two major types of calpain, including m-calpain and μ-calpain. DeepCalpain adopted four feature extraction methods to extract the sequence information and used a deep neural network to learn them, in the meanwhile, PSO (particle swarm optimizer) algorithm was used to fine turn the hyperparameters such as learning rate, layer numbers, activation functions and so on. DeepCalpain performed better than previous predictors for calpain-specific cleavage events.

About predicting performance

Web page introduction

Usage procedures

Output result explanation

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